Abstract

p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle.

LLU Discipline

Physical Therapy

Department

Physical Therapy

School

School of Allied Health Professions

First Advisor

Berk, Lee S.

Second Advisor

Daher, Noha S.

Third Advisor

Lohman, Everett

Fourth Advisor

Petrofsky, Jerrold S.

Degree Name

Doctor of Science (DSc)

Degree Level

D.Sc.

Year Degree Awarded

January 2013

Date (Title Page)

6-1-2013

Language

English

Library of Congress/MESH Subject Headings

Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;

Subject - Local

Sleep-wake cycle, Salivary melatonin, circadian rhythms, Homeostatic rhythms, Rhythm fragmentation

Type

Dissertation

Page Count

111 p.

Digital Format

Application/PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses & Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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