Abstract

The purpose of this study is to evaluate the bony augmentation of premaxillary clefts in humans using recombinant bone morphogenic protein (rhBMP-2) in a collagen sponge carrier. 12 patients with unilateral cleft alveolar ridges were evaluated pre- and 4 months postoperatively. 10 patients were repaired with rhBMP-2 while two others were grafted with anterior iliac crest particulate marrow cancellous bone (PMCB). Computed tomographic studies were used to evaluate preoperative alveolar cleft volumes, postoperative bone bridge volumes, and pre/post operative volume ratios.

A pre/post operative volume ratio for patients repaired with rhBMP-2 ranged from 24.1% to 90.6% with a mean of 71.7%. Patients who were grafted with PMCB had similar pre/post operative volume ratios ranging from 71.3% to 84.9% with a mean of 78.1%.

In conclusion, premaxillary alveolar clefts can have repair induced by rhBMP-2 as an effective alternative to conventional anterior iliac particulate marrow cancellous bone.

Department

Dentistry

School

Graduate Studies

First Advisor

Alan Herford

Second Advisor

Philip Boyne

Third Advisor

Wayne Tanaka

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

2006

Date (Title Page)

6-2006

Language

English

Library of Congress/MESH Subject Headings

Alveolar Ridge Augmentation; Cleft Palate -- surgery; Maxillofacial Abnormalities. Jaw Abnormalities. Bone Morphogenetic Protein.

Type

Dissertation

Page Count

1 vi; 24

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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