Abstract

There is evidence that homocysteine may be a factor in increasing the risk of coronary heart disease (CHD). To explore this relationship further, we assessed the interrelation of dietary vitamins B-6, B-12 and folate, and plasma pyridoxal-5'-phosphate and vitamin B-12 with plasma free and protein-bound homocysteine levels. Fasting blood and three-day dietary records were obtained from nine men low-risk (LR) and five at high-risk (HR) for CHD. The HR mean systolic blood pressure, total cholesterol (TC), and TC/cholesterol ratios were significantly higher than LR levels. Groups were comparable by age, weight, height, skinfolds, exercise, and smoking history. No significant difference was found for bound homocysteine between groups; however, mean free homocysteine differed significantly. Significant negative correlations were found between dietary vitamin B-6 and vitamin B-6:protein ratios with bound homocysteine and between plasma vitamin B-12 and free homocysteine. These data suggest that bound and perhaps free homocysteine levels may be decreased by increasing dietary vitamin B-6 and B-12 intake in humans.

Department

Nutrition

School

Graduate School

First Advisor

Terry D. Shultz

Second Advisor

James Blankenship

Third Advisor

Betty Kettering

Fourth Advisor

Albert Sanchez

Fifth Advisor

Bruce R. Wilcox

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1985

Date (Title Page)

9-1985

Language

English

Library of Congress/MESH Subject Headings

Coronary Disease; Homocysteine; Vitamin B 12; Pyridoxine

Type

Dissertation

Page Count

33

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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