Abstract

The in vivo and in vitro effects of cyclosporin A and corticosteroids on Trypanosoma musculi were examined. Mice that received continuous administration of 6 mg/liter/day of dexamethasone in drinking water and 200 mg/kg hydrocortisone acetate as a single dose 24 hrs prior to injection with T. musculi had significantly higher and longer parasitemias, than controls. Body and spleen weights and B cell responsiveness were lower in test animals and there were some deaths. Mice injected with T. musculi that received 100 mg/kg/day cyclosporin A had longer, but not higher, parasitemias than controls. Corticosteroids appear to partially inactive antibody production (i.e. ablastin), whereas cyclosporin A apparently has a minimal effect. The in vitro replication of T. musculi was decreased by hydrocortisone acetate (a high dosage) but not by cyclosporin A.

LLU Discipline

Microbiology

Department

Microbiology

School

Graduate School

First Advisor

Edward D. Wagner

Second Advisor

John E. Lewis

Third Advisor

Daila S. Gridley

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1988

Date (Title Page)

6-1988

Language

English

Library of Congress/MESH Subject Headings

Trypanosoma; Cyclosporins -- immunology; Adrenal Cortex Hormones -- immunology; Parasitic Diseases

Type

Thesis

Page Count

v; 25

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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