Xiaoxiao Tao

Abstract

We examined the major possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the BK subunit. Using molecular cloning, heterologous expression, and patch-clamp electrophysiology techniques, we elucidated a mechanism that, at least in part, contributes to the differences we observed between channels from native normoxic and LTH myocytes.

LLU Discipline

Pharmacology

Department

Basic Sciences

School

School of Medicine

First Advisor

Hessinger, David A.

Second Advisor

Buchholz, John N.

Third Advisor

Longo, Lawrence D.

Fourth Advisor

Mohan, Subburaman

Fifth Advisor

Watts, Kylie J.

Sixth Advisor

Zhang, Lubo

Degree Name

Doctor of Philosophy (PhD)

Degree Level

Ph.D.

Year Degree Awarded

2015

Date (Title Page)

6-2015

Language

English

Library of Congress/MESH Subject Headings

Anoxia; Hypoxia-Ischemia - Brain; Acclimatization; Altitude Sickness; Adaptation - Physiological; Myocytes; Potassium Channels - Calcium-Activated; Large-Conductance Calcium-activated Potassium Channels; Calcium Channel Blockers; Ion Channel Gating;

Subject - Local

Left Shift of the BK Channel; Basilar Artery Myocytes; Molecular Cloning; Heterologous Express; Patch-Clamp Electrophysiology;

Type

Dissertation

Page Count

127

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

Download

Share

COinS