The neuropathological effects of mild concussions can accumulate, leading to the development of motor and cognitive deficits. Although there are currently no treatments that can restore lost function after repetitive concussion, our laboratory has shown that dietary supplementation with pomegranate polyphenols can improve Alzheimer’s-like pathology, protect mice from the effects of proton irradiation, and protect humans from post-operative cognitive deficits. This study investigated the behavioral and neuropathological effects of repetitive concussions in mice and the use of dietary supplementation with pomegranate to ameliorate these effects. Adult mice were given dilute pomegranate juice or control water for 1 week, followed by anesthesia, repeated anesthesia (3 days apart), or repeated concussive injury (a single closed-head injury to each hemisphere 3 days apart). They were then maintained on the pomegranate juice or control water for 2 additional weeks. Behavioral testing was administered 1, 3, 5, and 7-11 days post injury to assess cognitive, motor, and affective functions. Repeated concussion, but not repeated anesthesia, induced motor and learning deficits, some of which were significantly reduced by pomegranate juice. These data suggest that the model of mild repeated concussive injury in mice might be used to test neuroprotective treatment in future studies.
School of Behavioral Health
Hartman, Richard E.
Dulcich, Melissa S.
Lee, Grace J.
Doctor of Philosophy (PhD)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Brain Injuries -- Pathology; Brain Injuries -- Psychology
Subject - Local
Pomegranates; Concussions; Cognitive Deficits; Polyphenols; Neuroprotective Treatments
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Bajwa, Nikita M., "The Effects of Mild Concussions and Pomegranates on Behavior" (2016). Loma Linda University Electronic Theses, Dissertations & Projects. 363.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives