p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (Ï=-.87; p=.001), wake after sleep onset (Ï =-.69; p=.02) and nocturnal activity (Ï =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (Ï =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle.
School of Allied Health Professions
Berk, Lee S.
Daher, Noha S.
Petrofsky, Jerrold S.
Doctor of Science (DSc)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;
Subject - Local
Sleep-wake cycle; Salivary melatonin; circadian rhythms; Homeostatic rhythms; Rhythm fragmentation
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Cavalcanti, Paula Regina Aguiar, "Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates" (2013). Loma Linda University Electronic Theses, Dissertations & Projects. 116.
Loma Linda University Electronic Theses & Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives