Studies were conducted to (1) investigate whether any protective factor is present in fresh water-cured olives or fresh cabbage as compared with the heated supplements against stress-induced gastric lesions in rats maintained on a nutritionally adequate diet for six weeks, (2) determine the relative protective factor in water-cured olives as compared with cabbage, (3) study the effect of black pepper in combination with fresh cabbage and olives and heated cabbage and olives in rats that were fed the same nutritionally adequate diet, and (4) investigate the effects of the same dietary components—cabbage and olives--on histamine- induced gastric lesions in guinea pigs fed guinea pig chow for five weeks.

At the end of the feeding period the rats were fasted and then stressed in quantitative stress cages and the guinea pigs were fasted and then injected intraperitoneally with histamine acid phosphate to produce gastric lesions. The effect of the diets on weight gain, number of lesions, and lesion area were analyzed statistically. The rats that were fed black pepper with heated or fresh cabbage or olives had considerably more lesions and a larger lesion area than those that had no spice. They also had a significantly reduced weight gain as compared to the control group. The animals on the spiced diets also lost much of their hair while the control groups maintained white fluffy coats. When the fresh cabbage or olive diets were compared to those with heated supplements no significant effect was found in either rats or guinea pigs. However, in the guinea pig experiments, the data showed that olives were significantly protective in both number and extent of lesions when compared with cabbage.

The rat study was done in two separate experiments under identical circumstances. However, the animals in the first experiment had a significantly greater lesion area as compared to all the animals from the second experiment. The reason for these results are not known. Further studies with animals and human beings are needed to establish the role of cabbage and olives in lesion prevention.




Graduate School

First Advisor

Marjorie V. Baldwin

Second Advisor

Albert Sanchez

Third Advisor

U. D. Register

Fourth Advisor

Bernell E. Baldwin

Degree Name

Master of Science (MS)

Degree Level


Year Degree Awarded


Date (Title Page)




Library of Congress/MESH Subject Headings

Stomach Ulcer; Diet Stress, Psychological



Page Count

vi; 38

Digital Format


Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.


Loma Linda University Electronic Theses and Dissertations

Collection Website



Loma Linda University. Del E. Webb Memorial Library. University Archives