Abstract

Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.

Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.

PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.

LLU Discipline

Physiology

Department

Philosophy

School

Graduate School

First Advisor

John Leonora

Second Advisor

Kenneth A. Arendt

Third Advisor

Robert W. Teel

Fourth Advisor

Elwood S. McCluskey

Degree Name

Doctor of Philosophy (Medical Science)

Degree Level

Ph.D.

Year Degree Awarded

1981

Date (Title Page)

6-1981

Language

English

Library of Congress/MESH Subject Headings

Salivary Glands; Insulin

Type

Dissertation

Page Count

ix; 99

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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