Abstract
The environmental carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause mutations which may then in turn lead to carcinogenesis. Certain nonnutritive plant compounds termed phytochemicals may protect against HCA and NNK-induced mutagenesis and carcinogenesis. We investigated the potential protective effects of five different phytochemicals of the flavonoid class which naturally occur in citrus. These flavonoids were diosmin, naringin. naringenin, rutin, and quercetin. Our results suggest that naringenin and quercetin were the strongest inhibitors of the metabolic activation of NNK, while diosmin, naringin, naringenin, and rutin each demonstrated protective effects toward HCA-induced mutagenesis.
LLU Discipline
Pharmacology
Department
Pharmacology
School
Graduate School
First Advisor
Robert W. Teel
Second Advisor
Raymond G. Hall
Third Advisor
Marvin Peters
Degree Name
Master of Science (MS)
Degree Level
M.S.
Year Degree Awarded
2002
Date (Title Page)
3-2002
Language
English
Library of Congress/MESH Subject Headings
Carcinogens, Environmental -- immunology; Bioflavonoids -- pharmacokinetics; Antioxidants -- chemistry; Anticarcinogenic Agents -- pharmacology; Flavones -- pharmacology; Enzyme Inhibitors -- pharmacology. Phytotherapy; Citrus -- chemistry.
Type
Thesis
Page Count
v; 71
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Bear, Wayne L., "Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens" (2002). Loma Linda University Electronic Theses, Dissertations & Projects. 1445.
https://scholarsrepository.llu.edu/etd/1445
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives