Post-treatment discomfort following endodontic procedures can be caused by inflammation due to injudicious use of intracanal medicaments. Camphorated paramonochlorophenol, metacresyl acetate, and prednisolone in combination is advocated to reduce the inflammatory potential of the germicide and thus reduce the occurrence of post-operative pain. It is imperative that a medicament retain antimicrobial activity while reducing inflammatory potential.

This investigation was undertaken toward determining on an in vitro quantitative bactericidal versus bacteriostatic basis by use of the broth dilution test tube method whether camphorated paramonochlorophenol, metacresyl acetate, and prednisolone in combination retains antimicrobial activity comparable to selected other commonly used nonspecific germicides. Four drugs--camphorated paramonochlorophenol (CMC), metacresyl acetate (Cresatin), camphorated paramonochlorophenol and metacresyl acetate in combination (XP-7) and camphorated paramonochlorophenol, metacresyl acetate and prednisolone in combination (CMP)--were tested against seven organisms: Candida albicans, Escherichia coli, Nocardia asteroides, Staphylococcus aureus, Streptococcus salivarius, Streptococcus faecalis, and Clostridium perfringens.

Based upon a statistical analysis, the following conclusions were made:

  1. There was no significant difference in the effectiveness of CMP compared to CMC and XP-7
  2. The addition of prednisolone to the non-specific germicide made no significant difference in the effectiveness of the drug as an antimicrobial agent.
  3. Cresatin was significantly less effective than CMC, XP-7, and CMP at the levels and dilutions used against the spectrum of microorganisms in this study.
  4. Streptococcus faecalis was the most resistant organism with Staphylococcus aureus slightly more resistant than the remaining organisms.


Graduate School

First Advisor

Ronald E. Buell

Second Advisor

Judson Klooster

Third Advisor

Edwin B. Nutting

Fourth Advisor

W. Eugene Rathbum

Fifth Advisor

Charles E. Winters

Degree Name

Master of Science (MS)

Year Degree Awarded


Date (Title Page)




Library of Congress/MESH Subject Headings

Dental Materials; Endodontics



Page Count

v; 69

Digital Format


Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.


Loma Linda University Electronic Theses and Dissertations

Collection Website



Loma Linda University. Del E. Webb Memorial Library. University Archives