Eight healthy male lacto-ovo-vegetarian subjects averaging 28.0 ± 3.6 years of age (22 to 53 years) were fed a diet rich in α-linolenic acid (18:3 ω 3) for four weeks. Arterial blood pressure and body weight were recorded each week. Plasma 6-keto-prostaglandin F1α (6-keto- PGF1α ), thromboxane B2 (TXB2), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.
Systolic blood pressure increased significantly between weeks 0 and 1 (106.5 ± 2.7 mmHg to 114.0 ± 3.7 mmHg; p < 0.003), but decreased to 107.3 t 2.6 mrHg (p < 0.02) at week 2. There was an insignificant increase in both systolic and diastolic blood pressures after four weeks. There was no significant change in either total cholesterol or triglyceride levels during the four weeks.
Plasma 6-keto-PGF1α levels increased significantly from 60.13 ± 8.50 pg/ml to 288.75 ± 33.44 pg/ml (p < 0.001) during the four weeks. Plasma TXB2 levels increased during the first two weeks (397.50 ± 25.34 pg/ml to 1576.25 ± 282.61 pg/ml; p < 0.005) then decreased to 814.29 t 122.74 pg/ml (p < 0.02) at week 4.
Plasma total phospholipid fatty acid analysis revealed a decrease in 18:2 ω 6 (p < 0.04), and an increase in 18:3 ω 3 (p < 0.02) and 20:5 ω 3 (p < 0.02) during the four week study.
James W. Blankenship
Ulma D. Register
W. Barton Rippon
Terry D. Shultz
Gerald W. Shavlik
Master of Science (MS)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Arteriosclerosis -- diet therapy; Linolenic Acids -- therapeutic use; Diet; Atherogenic; Cardiovascular Diseases -- diet therapy
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This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Lindbeck, Kelvin D., "The Effect of Dietary Alpha - Linolenic Acid on Apparent Risk Factors of Cardiovascular Disease" (1984). Loma Linda University Electronic Theses, Dissertations & Projects. 1544.
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