This study was undertaken to determine the antibacterial effects of various endodontic irrigants and medicaments against six selected anaerobic bacteria. In part 1, the organisms were mixed separately with dilutions of six irrigants in tubes containing fluid thioglycolate broth and allowed to remain in contact for specific time periods before being evaluated for growth. In part 2, the vapors of six medicaments were tested using agar plates streaked with the bacteria.
For part 1, the six irrigants were ranked as to their ability to inhibit bacterial growth. Statistical analysis showed that chlorhexidine and hydrogen peroxide were significantly more effective as antibacterial agents than calcium hydroxide and saline.
For part 2, a zone of inhibition was recorded for each plate and the results analyzed statistically. Formocresol produced significantly larger zones of inhibition than any of the other medicaments.
The results of this study indicated that chlorhexidine and formocresol were the most effective antibacterial agents under the test conditions.
School of Dentistry
James D. Kettering
Donald L. Peters
Master of Science (MS)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Bacteria, Anaerobic -- drug effects; Chlorhexidine -- therapeutic use; Dental Pulp Diseases -- therapy; Formocresols -- therapeutic use; Root Canal Irrigants -- analysis
1 v; 46
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Ohara, Patrick K., "Antibacterial Effects of Various Endodontic Irrigants and Medicaments on Selected Anaerobic Bacteria" (1992). Loma Linda University Electronic Theses, Dissertations & Projects. 1593.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives