A meta-analysis comparing the long-term effectiveness of cognitive behavioral therapy (CBT) and pharmacotherapy in preventing relapse following treatment discontinuation was performed using published studies of depressed participants. Twenty-three articles met inclusionary criteria and were included in the analyses. Weighted effect sizes and moderators, treatment type, were calculated using statistical analysis software. Initially, fixed effects models were applied to the data, but due to significant between-group heterogeneity that could not be fully explained by treatment type, mixed effect models were used to account for the residual heterogeneity. Results indicated that overall, depressed individuals treated to remission with CBT evidence decreased relapse rates up to 104 weeks post-treatment compared to those treated with pharmacotherapy. This finding was specifically supported at 52 weeks follow-up. However, while this finding was not significant at 104 weeks, the clear trend was in support of CBT. These findings have important implications for the effective long-term management of the recurrent nature of major depression.
Kendal C. Boyd
Louis E. Jenkins
David A. Vermeersch
Doctor of Psychology (PsyD)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Depression; Depressive Disorder -- therapy; Cognitive Therapy; Drug Therapy.
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Michel, Daniel B., "Efficacy of Cognitive Therapy and Pharmacotherapy In Depression: A Meta-Analysis" (2007). Loma Linda University Electronic Theses, Dissertations & Projects. 1596.
Loma Linda University Electronic Theses and Dissertations
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