Coronary artery disease (CAD), a consequence of coronary atherosclerosis, is the most common form of cardiovascular disease. Recent research suggests that compared to individuals with normal sleep duration, those with insufficient sleep, defined as short sleep duration (i.e., less than 6 hours per 24-hour period) have a 79% higher risk of developing coronary artery disease. In this review, selected physiological factors (including vascular inflammation, sympathetic overactivity, and increases in blood pressure), behavioral factors (including sedentary behavior and dietary choices), psychological factors (including hostility, fatigue, and major depressive disorder/depressive affect), and sociocultural factors (including race/ethnicity, socioeconomic status, and health literacy) were examined as they result from insufficient sleep and, downstream, to the onset of CAD. Based on the empirical literature published to date, a comprehensive model of CAD risk factors and the role of insufficient sleep is offered to highlight potential areas for new research. This review also proposes clinical implications including the development of more targeted assessment factors related to insufficient sleep and CAD onset, as well as the development of multifactorial treatment recommendations for those patients demonstrating risk factors (including insufficient sleep) to prevent CAD onset.
School of Behavioral Health
Janet L. Sonne
Tori R. Van Dyk
Doctor of Psychology (PsyD)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Cardiovascular Diseases--psychology.; Risk Factors; Sleep Deprivation
xi; 70 p.
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Raghani, Pooja S., "Insufficient Sleep and Onset of Coronary Artery Disease" (2022). Loma Linda University Electronic Theses, Dissertations & Projects. 1724.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives