The emergence of valid predictors of biological age has enabled researchers to test the effects of various interventions on biological aging processes. The established virtues of exercise and its effects on health and longevity make it a suitable candidate for investigation. This dissertation reviews the current state of biological age prediction models and presents a trial in which a specific exercise protocol’s ability to modulate biological age is tested. The specific protocol used is a 10X1 high-intensity interval training (HIIT) protocol, 10X1 referring to the quantity and duration of high intensity exercise intervals in each exercise session. The specific biological age prediction model chosen as the trial’s primary outcome measure relies on transcriptomic inputs to make biological age predictions. A significant difference in biological age was observed between groups. Reduction in biological age was observed in the exercise group, while increased biological age was observed in the control group. Exploratory, hypothesis generation analyses of gene expression revealed potential modification of autophagy, neurotrophin, and cancer biological pathways. This dissertation concludes that HIIT induces transcriptional changes which may in part account for the established beneficial effects of exercise on health and longevity.

LLU Discipline

Physical Therapy


Physical Therapy


School of Allied Health Professions

First Advisor

Gurinder Bains

Second Advisor

Lee Berk

Third Advisor

Steve Cole

Fourth Advisor

Lida Gharibvand

Fifth Advisor

Everett Lohman III

Degree Name

Doctor of Philosophy (PhD)

Year Degree Awarded


Date (Title Page)




Library of Congress/MESH Subject Headings

High-intensity interval training; Longevity; Transcriptome; Nerve Growth Factors; Outcome Assessment, Health Care



Page Count

xi, 186 p.

Digital Format


Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.


Loma Linda University Electronic Theses and Dissertations

Collection Website



Loma Linda University. Del E. Webb Memorial Library. University Archives