Traumatic brain injury (TBI) in children and infants is a primary cause of cognitive and behavioral problems that can persist through adulthood. In this study, the long-term behavioral effects of neonatal and juvenile TBI (jTBI) were characterized using mice. At an age of post-natal 7 or 10 days, mice underwent moderate or severe closed skull impact or sham surgery. Behavioral testing was conducted at 6 and 8 months post-injury. Tests administered included the open field activity (general activity levels), zero maze (anxiety), forced swim (depression), rotarod (coordination and balance), and water maze (general/spatial learning). jTBI mice showed elevated activity levels, impaired sensorimotor abilities, impaired spatial learning, and less efficient spatial search strategy use compared with sham animals. These differences were consistent and stable up to 8 months post-injury, suggesting that deficits acquired as the result of a TBI can have long-lasting behavioral impacts.
School of Science and Technology
Hartman, Richard E.
Master of Arts (MA)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Brain injuries; Trauma; Infant Behavior
Subject - Local
Longitudinal Behavioral Assessment -- Infants, Neonatal Traumatic Brain Injury
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Kamper, Joel, "Longitudinal Behavioral Assessment of Neonatal Traumatic Brain Injury" (2011). Loma Linda University Electronic Theses, Dissertations & Projects. 36.
Loma Linda University Electronic Theses & Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives