Tissue response toward injection by a "fluid-pressure" type apparatus, the Mizzy Syrijet, was evaluated by using dogs as the experimental animal.

The tongue was the organ of choice because it's size is sufficient to allow for several injections without overlapping tissue responses. In addition the two halves of the tongue are anatomically separated by a median raphe, providing for further isolation of injections.

The animals were injected at 12, 24, 48, 72 and 96 hour intervals utilizing the Syrijet on the right side of the tongue and needle on the left. Needle injection served as control for the microscopic comparison. Dog #1 was injected with 2% Carbocaine Hydrochloride, and dog #2 injected similarly with isotonic saline.

Microscopic sections of tissue injected with the Syrijet showed a significant amount of tissue disturbance such as inflammatory infiltration, edema, and free hemorrhage. A minimal response was seen in the needle injected sites, showing slight free hemorrhage and a little inflammation in some sections while in others no microscopic evidence of tissue reaction was noted.

Ignoring the time differential in comparing tissue damage between the Syrijet and needle statistically, the "T" test clearly indicated a significant difference in the amount of hemorrhage, swelling, tissue disturbance, cellular infiltrate, and free hemorrhage in Dog #1.

A similar response was also noted in dog #2 in the amount of swelling, tissue disturbance, and cellular infiltrate, and free hemorrhage.


Pathology and Human Anatomy


Graduate School

First Advisor

Elmer E. Kelln

Second Advisor

William P. Thompson

Third Advisor

Edwin M. Collins

Degree Name

Master of Science (MS)

Degree Level


Year Degree Awarded


Date (Title Page)




Library of Congress/MESH Subject Headings

Injections, Jet; Tongue



Page Count

vi; 62

Digital Format


Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.


Loma Linda University Electronic Theses and Dissertations

Collection Website



Loma Linda University. Del E. Webb Memorial Library. University Archives