Nancy Roberts


A high percentage of American women do not consume the Recommended Dietary Allowance for calcium. Marginal intake of calcium (Ca) in the years when peak bone mass is being formed may have a detrimental impact on bone later in life. This study looked at the effect of low Ca intake and other dietary components on serum and urine values of Ca as well as the response to repletion.

Seventeen free-living females, age 21 to 30 years, were placed on a low Ca diet (/day) for 22 days after a baseline of intake >800 mg/day for at least 6 weeks. Calcibind was given throughout the low Ca period to decrease Ca availability. Phosphorus intake was kept constant with Neutra-Phos-K supplementation. Seven days of repletion at >800 mg/day followed the low Ca diet. Blood and urine samples were collected 7 times. During the low Ca period energy, protein, and Ca intakes were significantly different from baseline and repletion. Sodium intake was significantly different only from baseline.

Mean serum Ca concentration significantly lower than baseline on days 2 and 3 of the low Ca diet. By day 22 on the diet, serum Ca had returned to baseline and remained unchanged throughout repletion. Urinary Ca values were significantly reduced during the low Ca diet and rapidly returned to baseline values during repletion.

A significant decrease in Ca intake resulted in significant reduction of several dietary components as well as urine and serum Ca levels, but healthy, young females adapted rapidly to repletion on a high Ca intake.




Graduate School

First Advisor

Patricia K. Johnston

Second Advisor

Robert Cruise

Third Advisor

U. D. Register

Degree Name

Master of Science (MS)

Degree Level


Year Degree Awarded


Date (Title Page)




Library of Congress/MESH Subject Headings

Calcium, Dietary -- pharmacokinetics; Osteoporosis -- therapy



Page Count

vi; 104

Digital Format


Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.


Loma Linda University Electronic Theses and Dissertations

Collection Website


Loma Linda University. Del E. Webb Memorial Library. University Archives