A clinical evaluation of acetyl-digitoxin
American Heart Journal
The advantages of the pure glycosides are well known. A new cardiac glycoside like acetyl-digitoxin therefore merits careful evaluation. Stoll and Kreins,1 prepared acetyl-digitoxin from lanatoside A by enzymatic cleavage of one molecule of glucose. The resulting compound is digitoxin with an acetyl group attached to the alpha carbon of the side chain. Chemical analysis by Stoll and Kreis showed that acetyl-digitoxin is a well defined pure glycoside which has no biologic assay variations. Rothlin2 and Löffler and co-workers3 have shown that acetyl-digitoxin is well absorbed, has excellent cardiotonic effects, and is less toxic than digitoxin. Löffler and associates placed acetyl-digitoxin midway between the glycosides digilanid and lanatoside C, and digitoxin in action. In this clinical report on acetyl-digitoxin we have stressed the dosage required for minimum effective digitalization, maintenance dose and toxicity, since there is disagreement concerning these features of the drug. © 1956, All rights reserved.
Gunther, Lewis; Baum, Richard N.; Elek, Stephen R.; John, Donald; and Levy, Ira, "A clinical evaluation of acetyl-digitoxin" (1956). LLU Faculty Publications. 129.