Title

Gestational hypoxia and epigenetic programming of brain development disorders

Document Type

Article

Publication Date

12-1-2014

Publication Title

Drug discovery today

E-ISSN

1878-5832

Abstract

Adverse environmental conditions faced by an individual early during its life, such as gestational hypoxia, can have a profound influence on the risk of diseases, such as neurological disorders, in later life. Clinical and preclinical studies suggest that epigenetic programming of gene expression patterns in response to maternal stress have a crucial role in the fetal origins of neurological diseases. Herein, we summarize recent studies regarding the role of epigenetic mechanisms in the developmental programming of neurological diseases in offspring, primarily focusing on DNA methylation/demethylation and miRNAs. Such information could increase our understanding of the fetal origins of adult diseases and help develop effective prevention and intervention against neurological diseases.

Volume

19

Issue

12

First Page

1883

Last Page

96

DOI

10.1016/j.drudis.2014.09.010

PubMed ID

25256780

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