Effects of Ginger Supplementation on Inflammation in Individuals
Master of Science in Nutrition and Dietetics Research Reports 2018
Background. Ginger is a widely used ingredient in Southeast Asian countries and has gained increasing popularity in the Western diet due to its purported health benefits. Ginger has high antioxidant power because of its rich phytochemistry profile that contributes to its anti- inflammatory properties. While there have been animal studies, the research of ginger’s effects in humans is limited.
Objective. We sought to understand ginger’s effects on commonly assayed inflammatory biomarkers—C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF- α)—in individuals with varying levels of physical activity. We propose that ginger may lower levels of these biomarkers due to its inherent anti-inflammatory characteristics.
Design. We designed an eight-week cohort study. Blood draw measurements were taken at three timepoints: the start of study, at week four, and upon completion of study.
Participants/setting. The study was conducted at Loma Linda University, where we enrolled twelve participants with a mean age of 42.4 ± 11.4 years who exercised at least once/week, did not take any anti-inflammatory medications, and who were free of any chronic inflammatory conditions.
Intervention. Participants were instructed to take three grams of ginger supplement mixed with lemonade powder to improve palatability daily. Participants also completed a pre- and post- intervention Short Form Health questionnaire (SF-36) to evaluate quality of life.
Main outcome measures. Inflammation was measured using three blood biomarkers: CRP, TNF-α, and IL-6. Quality of life was measured using the SF-36 questionnaire.
Statistical analyses performed. The three inflammatory biomarkers were analyzed using the Friedman non-parametric test and the Wilcoxon test where appropriate. The SF-36 questionnaire was analyzed using a paired t-test.
Results. Results of our study indicated a statistically significant reduction in TNF- α (p = .04) and a clinically significant reduction of greater than 15% in IL-6. There was a significant improvement in the domain of emotional well-being on the SF-36 after the ginger supplementation (p = .05).
Conclusions. Ginger may potentially be used as an adjuvant intervention in the prevention and management of chronic inflammatory diseases such as cardiovascular disease, diabetes, and obesity.
Nutrition and Dietetics
Nutrition and Dietetics
School of Allied Health Professions
Carter, James, III
Master of Science (MS)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Ginger; Anti-Inflammatory Agents; Biomarkers
Ginger; Inflammatory Biomarkers
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Kashlan, Sara; Rodriguez, Brenda; and Vuong, Monique, "Effects of Ginger Supplementation on Inflammation in Individuals" (2018). Loma Linda University Research Reports. 15.
Loma Linda University Research Reports
Loma Linda University. University Libraries.