Author

Tim Lekic

Abstract

Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.

LLU Discipline

Physiology

Department

Physiology

School

School of Medicine

First Advisor

Zhang, John

Second Advisor

Hartman, Richard

Third Advisor

Obenaus, Andre

Fourth Advisor

Ostrowski, Robert

Fifth Advisor

Tang, jiping

Degree Name

Doctor of Philosophy (PhD)

Degree Level

Ph.D.

Year Degree Awarded

2010

Date (Title Page)

9-2010

Language

English

Library of Congress/MESH Subject Headings

Cerebrovascular Disorders, Brain Edema, Disease Models - Animal, Cerebral Hemorrhage

Subject - Local

Stroke, Intracerebral Hemorrhage, Translational Research, Animal Models--Hemorrhage

Type

Thesis

Page Count

123

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

Included in

Physiology Commons

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