Abstract
Stroke is the third leading cause of death and is the leading cause of disability in the United States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are established according to intracerebral hemorrhage patient subpopulations, and characterized the neurobehavioral and morphological outcomes. These studies have established the requisite for future translational work to test neuroprotective drugs with the aim of improving the quality of life for these vulnerable patient populations.
LLU Discipline
Physiology
Department
Physiology
School
School of Medicine
First Advisor
Zhang, John
Second Advisor
Hartman, Richard
Third Advisor
Obenaus, Andre
Fourth Advisor
Ostrowski, Robert
Fifth Advisor
Tang, jiping
Degree Name
Doctor of Philosophy (PhD)
Degree Level
Ph.D.
Year Degree Awarded
2010
Date (Title Page)
9-2010
Language
English
Library of Congress/MESH Subject Headings
Cerebrovascular Disorders; Brain Edema; Disease Models - Animal; Cerebral Hemorrhage
Subject - Local
Stroke; Intracerebral Hemorrhage; Translational Research; Animal Models--Hemorrhage
Type
Thesis
Page Count
123
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Lekic, Tim, "Experimental Models of Brain Hemorrhage Using Clostridial Collagenase" (2010). Loma Linda University Electronic Theses, Dissertations & Projects. 166.
https://scholarsrepository.llu.edu/etd/166
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives