Abstract
Four groups of female Swiss Webster mice were injected intraperitoneally with similar volumes of normal saline, sonicated Trypanosoma musculi and saline, sonicated trypanosomes and Freund's Complete Adjuvant (FCA) and FCA. When the mice became immune and thus responded negatively to a T. musculi challenge, sera were collected and administered to four other groups of mice to establish passive immunity in these animals.
An established dose of innoculum of Trichinella spiralis larvae (8.1 larvae/gram of body weight) was given to all the mice by gastric gavage. These mice were killed 26 days later and the musculature digested with artificial gastric juice to release the encysted larvae.
The resulting larval mean counts indicated a slightly higher number of recovered larvae in the FCA control group than in the normal controls and the other two test groups. It is speculated that FCA may exert an unknown influence on some mechanism in the host mouse to permit enhancement of the larval development by suppression of the adult worm expulsion or the structural change of the host's intestinal wall due to the larvipository process.
The antibody, ablastin, may here suppress the development of the larvae in animals immunized against trypanosomes. The results in this experimental procedure show that concomitant exposure to both parasites may have a synergistic effect.
LLU Discipline
Biology
Department
Biology
School
Graduate School
First Advisor
Edward D. Wagner
Second Advisor
Leonard R. Brand
Third Advisor
Elmer A. Widmer
Degree Name
Master of Arts (MA)
Degree Level
M.A.
Year Degree Awarded
1979
Date (Title Page)
6-1979
Language
English
Library of Congress/MESH Subject Headings
Parasitic Diseases; Trypanosoma; Trichinella
Type
Thesis
Page Count
vi; 21
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Tan, Joan Chew Liang, "Concomitant Infections with the Parasites TRYPANOSOMA MUSCULI Kendall, 1906 and TRICHINELLA SPIRALIS (Owen, 1835) Raillet, 1896 in the Laboratory Mouse, MUSMUSCULUS" (1979). Loma Linda University Electronic Theses, Dissertations & Projects. 2478.
https://scholarsrepository.llu.edu/etd/2478
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives