Abstract
The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.
The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter
In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models showed increased risks of fatal NMRD with the relative risk (RR) of 1.13 [95% confidence interval (Cl), 1.04-1.22], 1.05 (95% Cl, 0.98-1.13) or 1.06 (95% Cl, 0.99-1.14) controlling for O3, NO2 or SO2, respectively. Also the RR of cancer mortality for each increment of 30 days/year of PM10 in excess of 100 pg/m3 was 1.16 (95% Cl: 1.03-1.31).
In the AHSMOG airport subcohort (n=3,239), the RR for fatal CHD with each 10 pg/m3 increase in PM2.5 was 2.00 (95 % Cl: 1.51, 2.64) in the two pollutant model with O3 in females. Corresponding RR’s for a 10 pg/m3 increases in PM10-2.5 and PM10 were 1.62 and 1.45, respectively, in all females. No significant associations were found in males.
A positive association with fatal CHD was found with all three PM fractions in females, but not in males. The risk estimates were more significant after adjustment for gaseous pollutants, especially O3. The risk estimates were the highest for PM2.5. Also, increased risks of NMRD and cancer mortality were found with ambient levels of PM10 and gases (O3, or SO2).
LLU Discipline
Epidemiology
Department
Epidemiology and Biostatistics
School
School of Public Health
First Advisor
Synnove M. F. Knutsen
Second Advisor
W. Lawrence Beeson
Third Advisor
Samuel Soret
Degree Name
Doctor of Public Health (DrPH)
Degree Level
Ph.D.
Year Degree Awarded
2010
Date (Title Page)
12-2010
Language
English
Library of Congress/MESH Subject Headings
Coronary Disease -- epidemiology -- United States; Coronary Disease -- in old age; Cardiovascular Diseases -- mortality; Risk Factor; Air Pollutants -- adverse effects; Air Pollution -- California; Environmental Exposure.
Type
Dissertation
Page Count
xi; 221
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Chen, Lie Hong, "Coronary Heart Disease Mortality and long-term Exposure to Ambient Particulate Air Pollutants in Elderly Nonsmoking California Residents" (2010). Loma Linda University Electronic Theses, Dissertations & Projects. 1136.
https://scholarsrepository.llu.edu/etd/1136
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives