Abstract
Recent investigations have shown that volume loading and alterations in body fluid osmolality cause rapid shifts throughout the body's fluid compartments in the adult dog. The lymph system has been found to be a vital link in the body's ability to compensate for excess fluid, and thus provides a strong defense against edema formation (Brace and Power, 1981; 1983). There have been no previous studies dealing with the investigation of whole-body lymph flow responses in the newborn. The purpose of this experimental research was to perform a systematic study into the whole-body lymph responses of newborn lambs to the particular variables of volume loading and variation in the osmolality of infused fluids.
Ten lambs, ranging in age from 1 to 12 days, were randomly divided into two groups, with five lambs in each group. Lymph flow from the thoracic duct was measured continuously while intravenous infusions of isotonic, hypertonic, and hypotonic saline were introduced in amounts equal to 2 percent of the total body weight. The infusion sequence was reversed in Group 2, i.e., isotonic, hypotonic, and hypertonic, respectively. Additional experimental variables such as hematocrit, lymph and plasma protein concentrations, and arterial and venous pressures were recorded at the same time.
This study showed that lymph flow doubled above the preinfusion control baseline following the initial volume loading with isotonic saline. Following the hypertonic infusion, lymph flow increased further by approximately 1.5 times above the isotonic level. Conversely, lymph flow responded to hypotonic saline infusions by increasing approximately 1.3-fold above the previous level.
Further findings indicated that the infused volume caused a rapid dilution of the red blood cells and plasma proteins, especially after the hypertonic solution. It was concluded that the hypertonic solution was the most effective stimulant for shifts in body fluid volumes, particularly regarding the interstitial fluid and lymph volumes.
This study also compared the excess lymph flow related to the change in interstitial fluid volume between newborn lambs and the adult dogs in a previous study by Brace and Power (1983). The findings suggest that newborns have an inherently higher baseline lymph flow than adults, and they exhibit a higher lymph flow response to fluid overload. This relatively high lymph flow in the newborn may be an important factor in the body's defense against edema.
LLU Discipline
Nursing
Department
Nursing
School
Graduate School
First Advisor
Clarice W. Woodward
Second Advisor
Gordon G. Power
Third Advisor
Lois Van Cleve
Degree Name
Master of Science (MS)
Degree Level
M.S.
Year Degree Awarded
1985
Date (Title Page)
6-1985
Language
English
Library of Congress/MESH Subject Headings
Lymphatic System; Edema -- prevention & control; Sheep -- physiology
Type
Thesis
Page Count
viii; 55
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Wickman, Debra S., "Lymph Flow in Newborn Lambs : Effects of Change in Osmolality" (1985). Loma Linda University Electronic Theses, Dissertations & Projects. 1143.
https://scholarsrepository.llu.edu/etd/1143
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives