Abstract

Previous work conducted in our laboratory has shown that steroid hormones bind to natural (e.g., brans, oat hulls) and purified (e.g., cellulose, lignin) fiber components. To explore this relationship further, we assessed the in vitro binding of estrone, estradiol-17β, and testosterone to a water-insoluble fiber fraction obtained from composite food samples of 18 Seventh-day Adventist (SDA) nonvegetarian (NV), 20 SDA lacto-ovovegetarian (LOV), and 15 SDA vegan (V) men. Three-day dietary food records and 72-hr food composites were obtained contemporaneously from each subject. The LOV and V subjects consumed significantly more crude, dietary and water-insoluble fiber than the NV subjects. Water-insoluble fiber bound an average of 73% of all estrogens tested, and 56% of the testosterone. Binding levels of testosterone were significantly higher in the Vs than in the LOVs and omnivores. Additionally, there was a significant relationship, for all groups combined, between water insoluble fiber intakes and binding of estrone and testosterone. These results suggest that diet may modify hormonal status, possibly through binding of steroid hormones by dietary fiber, leading to altered enterohepatic circulation of these hormones.

Department

Nutrition

School

Graduate School

First Advisor

Terry D. Shultz

Second Advisor

David C. Nieman

Third Advisor

U. D. Register

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1987

Date (Title Page)

12-1987

Language

English

Library of Congress/MESH Subject Headings

Hormones -- physiology; Dietary Fiber

Type

Thesis

Page Count

iii; 28

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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