Don Dornan

Abstract

This thesis describes an in vivo perfusion apparatus which can continuously deliver controlled quantities of solutions to localized, contralateral intra oral areas in albino rats. Three animals were per fused on the experimental area (the mesial sulcular area of the maxillary first molar) on one side with tap water and trypan blue. Localization of the solution delivered and minimal histological changes due to the presence of the apparatus was demonstrated on these animals. A 1% solution of trypsin was perfused on the experimental area of one animal for one day at the rate of 4.8 ml/day and on another animal for four days at the same rate. A 1% pronase solution was perfused for four days on one animal at the rate of .96 ml/day and another animal at 4.8 ml/day. The appropriate control solutions were delivered on the contralateral side of each animal undergoing enzyme perfusion. Data obtained indicated moderate inflammatory changes were noted on the side receiving the enzyme. More meaningful results should be obtained with the modifications discussed in this report.

LLU Discipline

Periodontics

Department

Periodontics

School

Graduate School

First Advisor

Richard C. Oliver

Second Advisor

Edwin M. Collins

Third Advisor

G. Conrad Hornbuckle

Fourth Advisor

Eugene Rathbun

Fifth Advisor

John De Vincenzo

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1969

Date (Title Page)

5-1969

Language

English

Library of Congress/MESH Subject Headings

Gingival Diseases

Type

Thesis

Page Count

vii; 58

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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