The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth

Author

Mara D. Velkers

Abstract

Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C¹⁴-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C¹⁴ bromide into PC was decreased and the incorporation of ethanolamine-UL-C¹⁴ HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity.

Department

Nutrition

School

Graduate School

First Advisor

James Blankenship

Second Advisor

U. D. Register

Third Advisor

R. Bruce Wilcox

Fourth Advisor

Raymond O. West

Fifth Advisor

Allen Strother

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1972

Date (Title Page)

5-1972

Language

English

Library of Congress/MESH Subject Headings

Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines

Type

Thesis

Page Count

vii; 44

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Copyright

Author

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Recommended Citation

Velkers, Mara D., "The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth" (1972). Loma Linda University Electronic Theses, Dissertations & Projects. 1223.
https://scholarsrepository.llu.edu/etd/1223

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives