Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C14-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C14 bromide into PC was decreased and the incorporation of ethanolamine-UL-C14 HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity.
U. D. Register
R. Bruce Wilcox
Raymond O. West
Master of Science (MS)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Velkers, Mara D., "The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth" (1972). Loma Linda University Electronic Theses, Dissertations & Projects. 1223.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives