Abstract

The 51Chromium release assay was used to measure natural killer (NK) cell activity associated with Corynebacterium parvum (CP) injection against YAC-1 and MBT-2 targets. The peritoneal exudate cells from intraperitoneal treatment of CP at different dosages consistently gave higher cytotoxicity than their respective spleen cell fractions. In contrast, CP given intravenously showed the reversed effect. Our results demonstrate that the route of administration and dosage of CP are two crucial variables for determining the effectiveness of this immunostimulant. In vitro manipulations of nordihydroguaiaretic acid, indomethacin, and prostaglandin E2 on CP-stimulated NK cells suggest that the lipoxygenase pathway is involved in NK lysis.

LLU Discipline

Microbiology

Department

Microbiology

School

Graduate School

First Advisor

Benjamin H. S. Lau

Second Advisor

James D. Kettering

Third Advisor

Robert W. Teel

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1986

Date (Title Page)

6-1986

Language

English

Library of Congress/MESH Subject Headings

Killer Cells, Natural; Propionibacterium acnes; Immunotherapy

Type

Dissertation

Page Count

ii; 18

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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Included in

Microbiology Commons

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