Alisa Minear

Abstract

Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C14-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.

Department

Nutrition

School

Graduate School

First Advisor

James W. Blankenship

Second Advisor

Stewart W. Shankel

Third Advisor

Kathleen K. Zolber

Fourth Advisor

Irma B. Vyhmeister

Fifth Advisor

Winston J. Craig

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1980

Date (Title Page)

6-1980

Language

English

Library of Congress/MESH Subject Headings

Hemodialysis; Lipoprotein Lipase; Acute Kidney Injury

Type

Thesis

Page Count

vi; 62

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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