Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C14-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as evidenced by a 22-66% inhibition of lipolytic activity by the ultrafiltrate. It is proposed that the triglyceride-lowering effect observed by others subsequent to hemofiltration treatments is a result of the removal of one or more inhibitors of lipoprotein lipase from the plasma of hypertriglyceridemic renal failure patients.
James W. Blankenship
Stewart W. Shankel
Kathleen K. Zolber
Irma B. Vyhmeister
Winston J. Craig
Master of Science (MS)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Hemodialysis; Lipoprotein Lipase; Acute Kidney Injury
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Minear, Alisa, "Lipoprotein Lipase Inhibitor Removal During Ultrafiltration of Renal Failure Patients" (1980). Loma Linda University Electronic Theses, Dissertations & Projects. 1597.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives