Abstract

Background/Purpose: Obesity is fast becoming a worldwide epidemic. Bariatric Surgery (BS) is an effective treatment to decrease obesity and the risk of associated diseases. The purpose of this study was to examine the effect of probiotics and prebiotics (LactoWise®) on weight loss, clinical lab values, and quality of life in morbidly obese patients undergoing LSG.

Methods: Sixty patients undergoing LSG were recruited to participate in the study and randomized into either a LactoWise® or placebo group. The LactoWise® group received 4.5 billion live cells of bacillus coagulans and galactomannans (300 mg); the placebo group received 600 mg of calcium citrate yielding 126 mg of elemental calcium. Both groups took their assigned capsule daily for 3-months post-surgery. Standard clinical lab values were measured pre-surgery and at 3-months post-surgery. Weight, blood pressures, and quality of life using the GIQLI were measured at baseline, 2-weeks, 6-weeks, and 3-months post-surgery.

Results: The labs, blood pressure, and weight loss data for a total 35 patients with a mean age of 47.7±12.4 years and a mean body mass index (BMI) of 46.6±8.2 kg/m2 were collected. For the quality of life measurements using the GIQLI, data was collected on a total of 40 of patients. There was a significant difference in BMI at baseline between the two study groups (43.0±7.0 vs. 49.2±8.3, p=0.02). Weight loss was greater in the LactoWise® group compared to placebo at 6-weeks but showed no significant difference at 3 months post-op. There was a significant drop in triglycerides (TG) over time (p=0.02), and this change was significant between the two groups (p=0.01). The LactoWise® group had a significant decrease in AST compared to the placebo group (p=0.03). In terms of quality of life, the LactoWise® and placebo groups, there was a significant change in median quality of life over time (p<0.001). Pairwise comparison showed that there was a significant difference between baseline and each time index evaluated (2-weeks, 6-weeks and, 3-months) (p<0.01).

Conclusions: Bariatric surgery (BS) produces positively impacting metabolic results in morbidly obese patients. Our study showed that in the case of weight loss, TG, and AST administering of a probiotic/prebiotic blend may play a role in improving clinical outcomes of morbidly obese patients undergoing LSG. In terms of quality of life, the study results did not show significant changes between groups with the GIQLI.

LLU Discipline

Rehabilitation Sciences

Department

Rehabilitation Sciences

School

School of Allied Health Professions

First Advisor

Grenith Zimmerman

Second Advisor

Noha Daher

Third Advisor

Keith Scharf

Degree Name

Doctor of Philosophy (PhD)

Degree Level

Ph.D.

Year Degree Awarded

2018

Date (Title Page)

6-2018

Language

English

Library of Congress/MESH Subject Headings

Obesity, Morbid; Quality of Life; galactomannan; Bacillus coagulans; Calcium Citrate; Bariatric Surgery

Type

Dissertation

Page Count

xi, 82 p.

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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