This article discusses the current information on the mechanism of the biological signaling that takes place to bring about orthodontic tooth movement.
Currently, there are two general theories as to how orthodontic mechanical force is translated to biologically meaningful signals for the cells of the periodontium. These include a cellular-humoral response and a bioelectric response.
There are various mechanisms utilized by the cells of the periodontium to bring about the cellular-humoral response. These include: The activation of the cells of the immune system to synthesize and release specific chemicals (cytokines) which affect cell function, direct effects of mechanical force on the cells of the periodontium, and changes in the local oxygen availability caused by the application of force.
The bioelectric response involves the generation of two types of electrical signals: A piezoelectric potential generated from the distortion of the hydroxylapatite crystals and a bioelectric potential generated from the metabolically active cells of the alveolar bone.
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Library of Congress/MESH Subject Headings
Tooth Movement, Minor; Immune System; Cell Communication; Mast Cells; Monocytes; Cytokines; Cytoskeleton; Prostagladins
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This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Yazdi, Mohamadreza, "Current Theories on the Cell Biology Associated with Tooth Movement" (1995). Loma Linda University Electronic Theses, Dissertations & Projects. 1863.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives