Abstract

The pulps of mandibular molars of 15 athymic and 15 conventional rats were surgically exposed and left open to their oral flora. Each group was divided into 3 subgroups of 5 animals each. The rats were sacrificed after their pulps were exposed for 2, 4, or 8 weeks. After fixing, decalcifying, and embedding, the specimens were sectioned and stained with H and E. They were then examined under a microscopic grid and quantified by percentages of surface areas of bone, connective tissue, bone marrow, intrabony spaces, periapical lesions, and numbers of osteoclasts. This was done using a DataVoice computerized data collection and analysis system. Statistical analysis showed no significant difference between periapical tissue responses of the two treated groups. However, there was a significant difference between periapical tissue response of untreated molars of conventional rats compared to those whose pulps had been surgically exposed. The results indicate that the pathogenesis of periapical lesions is a multifactorial phenomenon and is not totally dependent on the presence of T cell lymphocytes.

Department

Dentistry

School

Mahmoud Terabinejad

First Advisor

William Eby

Second Advisor

James D. Kettering

Third Advisor

Susan D. Richards

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1991

Date (Title Page)

6-1991

Language

English

Library of Congress/MESH Subject Headings

Periapical Diseases -- pathology; T-Lymphocytes -- pathology

Type

Thesis

Page Count

iii; 19

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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