Abstract

This study compared the ability of three different bone growth factor combinations with that of Ca(OH)2 to stimulate apical closure as well as the effectiveness of Mineral Trioxide Aggregate (MTA) as an apical barrier. Fifty-six roots of second and fourth mandibular premolars of seven six- month old beagle dogs were used. Periradicular lesions were created over a four week period. The canals were cleaned and shaped and filled with Ca(OH)2 for one week. They were then irrigated and received one of seven different treatments in a balanced design. Growth factors were placed in a carboxymethylcellulose carrier and delivered to the canals as follows. Group I received 0.5μg Transforming Growth Factor-β (TGF-β) and 25μg Insulin Like Growth Factor-1 (IGF-1). Group II received 5 μg TGF-β and 25 μg Platelet Derived Growth Factor (PDGF). Group IV received the carrier alone. Canals in Group V canals were filled with Ca(OH)2. Canals in group VII were obturated with MTA. Canals in Group VII received no further treatment. The animals were euthanized after nine weeks. Degree of apexification and lesion size were assessed radiographically and histologically. Data was analyzed with a repeated measures ANOVA. Groups I, IV, V, and VI produced statistically significantly (p < .05) greater amounts of osteodentin than group VII. There was no statistically significant differences in lesion size. However, MTA had the smallest lesions histologically and radiographically. Based on these results it appears that bone growth factors can stimulate apical closure, and MTA can be used as a one step obturation material in teeth with open apecies.

Department

Dentistry

School

Graduate School

First Advisor

Mahmoud Torabinejad

Second Advisor

John Farley

Third Advisor

Thomas Linkhart

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1977

Date (Title Page)

3-1977

Language

English

Library of Congress/MESH Subject Headings

Apicoectomy -- methods; Calcium Hydroxide -- therapy; Platelet Derived Growth Factor; Transforming Growth Factor beta; Bone Morphogenetic Proteins

Type

Thesis

Page Count

vii; 2, 63

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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