Abstract

Periodontal regeneration includes the formation of both alveolar bone and cementum. Studies reporting histologic evidence of healing following periodontal reconstructive therapy were reviewed to determine whether regeneration of these structures improves with increasing healing interval, and whether they regenerate independently or whether regeneration of one structure is dependent upon regeneration of the other. Additionally, the review addresses whether specific reconstructive modalities predictably yield increased amounts of regeneration. Differences in regenerative potential between humans, nonhuman primates, and canines were also examined. Results of over a decade of studies of periodontal reconstructive therapy were tabulated by family (human, nonhuman primate, and canine) and modality employed. Graphs were derived to illustrate regeneration over time and regeneration of alveolar bone regeneration relative to that of cementum. Although it is difficult to make precise comparisons between studies due to lack of standardized experimentation, the following conclusions were made: 1) Smaller amounts of alveolar bone and cementum regeneration have been observed at very early compared to later observation intervals. A sufficient healing interval appears necessary to secure optimal regeneration. 2) Alveolar bone and cementum appear to regenerate independently; however, increased amounts of bone regeneration often are accompanied by larger than average cementum regeneration. 3) All reconstructive modalities appear unpredictable for clinically meaningful alveolar bone and cementum regeneration. 4) Regeneration of alveolar bone usually does not exceed 3 mm in the apicocoronal dimension in the examined families. Regeneration of cementum usually does not exceed 3 mm in humans and nonhuman primates. However, exceptional observations have been made for both alveolar bone and cementum. 5) Standardization of protocol for evaluation of periodontal reconstructive therapy may make future comparisons of studies more meaningful.

LLU Discipline

Periodontics

Department

Periodontics

School

Graduate School

First Advisor

Ulf M. E. Wikesjö

Second Advisor

Knut A. Selvig

Third Advisor

Thorarinn J. Sigurdsson

Fourth Advisor

Grenith Zimmerman

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1995

Date (Title Page)

8-1995

Language

English

Library of Congress/MESH Subject Headings

Alveolar Bone Loss; Bone Regeneration; Dental Cementum; Periodontal Diseases -- surgery; Bone Substitutes

Type

Thesis

Page Count

2 xii; 133

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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