Abstract

The action of a chemotherapeutic agent as a tool in studying its effect upon a primary growth center, the mandibular condyle, was investigated. So far as can be ascertained, no studies have been reported where these growth sites have been eliminated or modified by the use of chemotherapeutic growth inhibitors.

Observation of mandibular and alveolar growth following the infusion into the left external carotid artery of a cancer chemotherapeutic agent, 5-Fluorouricil (Roach-Hoffman), was noted. Comparisons were made between the infused and the uninfused sides of the mandible observing gross growth changes.

Four dogs, aged 75 days, were infused with varying dosages of 5- Fluorouricil, with one fatality. In another dog only the left external carotid artery was ligated with no infusion. These four animals survived an adequate growth period and were then sacrificed. Various bilateral comparative measurements were made directly upon the mandibular specimens. Shortening of the mandibular length on the infused side was the most significant change observed, being valid at the 0.1 significance level.

LLU Discipline

Orthodontics

Department

Dentistry

School

Graduate School

First Advisor

Alden B. Chase

Second Advisor

Edwin M. Collins

Third Advisor

Ariel A. Roth

Fourth Advisor

Alvin V. Schiess

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1967

Date (Title Page)

6-1967

Language

English

Library of Congress/MESH Subject Headings

Jaw; Growth; Fluorouracil

Type

Thesis

Page Count

vi; 35

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

Download

Share

COinS