Abstract

Endodontic or root canal infection results in immunologic changes in periapical region, which causes the destruction of pulpal and periapical tissue. No definitive study has identified a specific organism or a group of organisms as a etiological agents. Past studies have indicated that immunoglobulin E play a significant role in the pathogenesis of periapical lesions. The presence of this factor suggests that some of the endodontic flare-ups may be IgE-mediated hypersensitivity reactions. Antibody levels of IgA have been quantitatively measured by ELISA and IgE by modified RAST assay, against eleven oral bacteria which are routinely isolated from such lesions. The experimental groups consisted of normal, acute and chronic dental populations. Statistical analysis of the results for IgA indicates a significant difference in antibody levels against Streptococcus sanguis between acute and chronic lesions. For IgE, no significant differences were observed among the three experimental groups. The evidence of IgE secreting cells have been confirmed by indirect immunoperoxidase technique using Avidin-Biotin method. All of these observations suggests that the etiology involved in the formation of endodontic lesions is multiple in nature, and not resulting from a single organism.

LLU Discipline

Microbiology

Department

Microbiology

School

Graduate School

First Advisor

James D. Kettering

Second Advisor

Benjamin Lau

Third Advisor

Paul McMillan

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1988

Date (Title Page)

6-1988

Language

English

Library of Congress/MESH Subject Headings

Periapical Abscess -- etiology; Bacteria -- immunology

Type

Thesis

Page Count

v; 49

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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