Abstract

Prostaglandins (PG) have been implicated in pathogenesis of periapical lesions. The purpose of this study was to determine the concentrations of PGE2 in human periapical lesions. Periapical specimens from patients with clinical signs and symptoms of chronic and acute apical periodontitis were obtained and immediately frozen in liquid nitrogen. Periradicular tissues from unerupted third molars were frozen and used as controls. The concentration of PGE2 was determined by radioimmunoassay. Low levels of PGE2 were found in the control tissues as compared to those detected in chronic and acute lesions. A significantly higher level of PGE2 was found in acute lesions in comparison to those found in chronic lesions. The results show that acute lesions have higher concentrations of PGE2 than chronic lesions. The findings indicate that this substance participates in pathogenesis of human periapical lesions.

Department

Dentistry

School

Graduate School

First Advisor

Mahmoud Torabinejad

Second Advisor

James Blankenship

Third Advisor

Leif Bakland

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1989

Date (Title Page)

8-1989

Language

English

Library of Congress/MESH Subject Headings

Periapical Abcess -- etiology; Dinoprostone

Type

Thesis

Page Count

iii; 87

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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