Hugh Maguire

Abstract

The purpose of this study was to evaluate the effects of the resorbable membrane Guidor™ and the osteogenic protein hOP-1 on hard tissue healing following periradicular surgery in cats.

Surgical endodontic therapy was performed on the maxillary canine teeth of twelve cats. After orthograde root canal therapy, flap reflection, osteotomy, resection of the root end, root end cavity preparation and the placement of a root end filling, eight of the surgical sites were treated with Guidor™ and eight with hOP-1. The remaining eight sites received no further treatment and served as controls.

The animals were sacrificed at twelve weeks following the periapical surgeries. Block sections containing the maxillary canine teeth and surrounding tissue were then removed and examined histologically.

The results showed that the use of Guidor™ membrane had no statistically significant effect on osseous healing, or cementum formation on the resected root ends. It was, however, associated with the presence of a significantly greater number of inflammatory cells at the surgical site (p < 0.05). The use of the osteogenic protein hOP-1 had no statistically significant effect on the osseous healing of the surgical site or the number of inflammatory cells present. However, its use was associated with a significant (p < 0.05) decrease in the thickness of new cementum formed on the resected root ends.

Department

Dentistry

School

Graduate School

First Advisor

Mahmoud Torabinejad

Second Advisor

Douglas McKendry

Third Advisor

Paul McMillan

Fourth Advisor

James H. Simon

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1996

Date (Title Page)

6-1996

Language

English

Library of Congress/MESH Subject Headings

Dental Pulp Diseases -- surgery; Surgery, Oral; Tissue Conditioning (Dental)

Type

Thesis

Page Count

2 vi; 115

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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