Gerald C. Lim

Abstract

Interleukin 1-Beta has been shown to be a potent mediator of bone resorption and has been implicated in resorption in periradicular lesions. In this study we compared the local concentrations of IL-1β in symptomatic and asymptomatic human periradicular lesions. Periradicular tissues from patients with symptomatic and asymptomatic lesions were obtained and stored at -70°C. Pulpal tissues from unerupted third molars and chronically inflamed gingival tissues were also obtained and used as negative and positive controls, respectively. Tissue samples were homogenized, and supernatants were assayed for IL-1β by ELISA. Significantly higher levels of IL-1β were found in symptomatic and asymptomatic lesions and inflamed gingival tissues compared to uninflamed pulp tissues. There was a strong trend toward higher levels of IL-1β in symptomatic lesions compared with asymptomatic lesions, but the difference was not significant. The results suggest that IL-1β may play a significant role in the pathogenesis of human periradicular lesions.

Department

Dentistry

School

Graduate School

First Advisor

Mahmoud Torabinejad

Second Advisor

Richard Finkelman

Third Advisor

James Kettering

Fourth Advisor

Thomas Linkhart

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1993

Date (Title Page)

Summer 1993

Language

English

Library of Congress/MESH Subject Headings

Interleukin-1 -- adverse effects; Periapical Diseases -- microbiology; Tooth Resorption -- etiology

Type

Thesis

Page Count

iii; 12

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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