Abstract

Bone morphogenetic proteins (BMPs) have been shown to induce bone formation in ectopic and orthotopic sites. This inductive capability has led to their evaluation as possible adjuncts in periodontal reconstructive therapy. Indeed, studies have reported periodontal regeneration following surgical implantation of recombinant human BMP-2. This study evaluated regeneration of alveolar bone and cementum following periodontal reconstructive surgery including implantation of a construct consisting of sterile lyophilized rhBMP-2 in buffer adsorbed onto an absorbable collagen sponge. Critical size mandibular supra-alveolar periodontal defects were surgically created, and an incomplete block design was used to evaluate the regenerative potential of rhBMP-2 at 0.05, 0.1, and 0.2 mg/mL. A control outside the model was used to affirm any effect of the carrier system alone. The animals were sacrificed at week eight post-surgery and block sections were collected and processed for histometric analysis. The defect height, regenerated bone height, cementum regeneration, ankylosis, and root resorption were evaluated. The results confirm previous reports that rhBMP-2 induces significant alveolar bone regeneration in critical size, supra-alveolar defects in dogs. No differences were observed between the rhBMP-2 dosages. Appreciable cementum regeneration was limited and similar in defects receiving rhBMP-2. In addition, ankylosis was observed in almost all teeth receiving rhBMP-2. Control defects exhibited limited, if any, evidence of alveolar bone and cementum regeneration, or ankylosis. Within the selected rhBMP-2 dosage and observation interval, there are no meaningful differences in regeneration of alveolar bone and cementum. There are also no meaningful differences in root resorption and ankylosis.

LLU Discipline

Periodontics

Department

Periodontics

School

Graduate School

First Advisor

Ulf M.E. Wikesjö

Second Advisor

Nicholas Caplanis

Third Advisor

Charles J.C. Kean

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1998

Date (Title Page)

6-1998

Language

English

Library of Congress/MESH Subject Headings

Bone Morphogenetic Proteins; Periodontal Diseases; Periodontics -- therapy

Type

Thesis

Page Count

vii: 50

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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