Edgar Grageda

Abstract

Recently Platelet-Rich Plasma has been proven to be an effective regeneration adjunct when combined with autogenous bone in the reconstruction of mandibular defects. However, little is known about the effect of PRP when combined with a bone allograft in the maxillary sinus.

The purpose of this study was to quantitatively evaluate the ability of PRP to enhance bone regeneration in the maxillary sinus of sheep when combined with DFDBA + CCFDBA. Ten sheep were selected for bilateral sinus augmentation DFDBA + CCFDBA + PRP (test) and DFDBA + CCFDBA (control). Five were sacrificed at 3 months and the other five at 6 months. Hematology tests were performed for platelet count and histology slides were obtained for histomorphometric analysis taking two measures of interest: total tissue area (sq mm) and % trabecular bone filled.

Student's t- test showed no significant difference between test and control groups for total tissue area (p > 0.25) and % trabecular bone fill (p > .80) at either 3 or 6 months. The control group showed no statistical difference for total tissue area (p < .095) and % trabecular bone fill (p < .60) between 3 and 6 months healing times. The test group, however, showed a significant increase in total tissue area ( p < .025), but not in % trabecular bone fill (p < .40) for the two healing periods.

When the treatments were compared for interactions within the animal model, there was no clear tendency for the test group to perform in relation to the control group regarding total tissue area (r = 0.766, p < .01). A moderate tendency existed between the % bone trabecular fill (r = .824, p < .005). PRP showed higher platelet count than the whole blood (2 to 5 times). However, no correlation was found between the log ratio and the bone measures.

Within the limitations of this study, PRP when combined with bone allograft failed to enhance and/or accelerate bone regeneration in the maxillary sinus of sheep when combined with bone allograft

LLU Discipline

Implant Dentistry

Department

Implant Dentistry

School

Graduate School

First Advisor

Jaime L. Lozada

Second Advisor

Philip J. Boyne

Third Advisor

Nicholas Caplanis

Fourth Advisor

Paul J. McMillan

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

2004

Date (Title Page)

6-2004

Language

English

Library of Congress/MESH Subject Headings

Bone Regeneration; Maxillary Sinus -- anatomy and histology; Mandible -- abnormalities; Mandible -- surgery; Platelet Count

Type

Thesis

Page Count

xii; 70

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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