Pilseong Kim

Abstract

Wound healing is a complex biologic process that involves chemotaxis and division of cells, neovascularization, synthesis of extracellular matrix proteins, and remodeling of the repaired tissues. Of equal importance is the restoration of normal tissue structure and function without scar formation. The aim of this study was to find out the clinical effects of anti-TGFß1 and Pycnogenol® on scarless wound healing on rat skin.

An acute incision wound model was used with 20 healthy rats. Four incisions were made on each rat's skin and 4 different variables were applied by local infiltration. The four variables were anti-TGFß1, Pycnogenol®, PBS, and no treatment. All injected on the day of the wound induction, and 36 hours later. Clinical observation and scoring was done 28 days after the wound induction. Biopsies of each site were obtained for histological comparison.

There were no statistical differences among each treatment on scar formation after 28 days of incision wound clinically and histologically. Marked histological difference in collagen apposition in the scarred areas compared to the normal dermis was observed.

LLU Discipline

Periodontics

Department

Periodontics

School

Graduate School

First Advisor

Shahrokh Shabahang

Second Advisor

Max Crigger

Third Advisor

Benjamin H.S. Lau

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

2004

Date (Title Page)

6-2004

Language

English

Library of Congress/MESH Subject Headings

Cicatrix -- anatomy and histology; Flavonoids -- therapeutic use; Wound Healing

Type

Thesis

Page Count

ix; 29

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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