Hsiu Fen Liu

Abstract

The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.

Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats (p < .001). In addition, the higher level of dosage was more effective in reducing the alcohol intake. The growth rate was decreased in rats treated with codeine (p < .05).

An attempt was made to find differences in dopamine metabolism of heavy alcohol-drinking rats and non-drinkers. The study was also conducted to trace morphine-like compounds in the urine of alcohol-drinking rats after dopamine or radioactive dopamine injections. The identity of morphine was determined by gas chromatography and thin-layer chromatography; however, no [measureable] amount was observed.

Department

Nutrition

School

Graduate School

First Advisor

U. D. Register

Second Advisor

James W. Blankenship

Third Advisor

Paul Y. Yahiku

Fourth Advisor

Charles C. Hunter

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1974

Date (Title Page)

12-1974

Language

English

Library of Congress/MESH Subject Headings

Alcohol Drinking; Morphine; Codeine; Dopamine

Type

Thesis

Page Count

vi; 48

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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