Abstract

Problem drinkers (N=7) were given 500mg disulfiram daily for one week. Urine was collected before and after disulfiram intake. 5-Hydroxytryptophol (5-HTOL) was determined by a modification of the method of Davis et al. and adapted to high-performance liquid chromatography (HPLC) with an electrochemical detector setting of 0.75V. 5-Hydroxy-indoleacetic acid (5- HIAA) was determined using the HPLC method of Shihabi et al. (1980). Urinary excretion of 5-HTOL in ug/gm creatinine before and after disulfiram was 25.4± 3.3 and 110.5± 27.1 respectively, p < 0.02. 5-HIAA in mg/gm creatinine before and after disulfiram was 4.9±0.9 and 3.6±0.8 respectively, p > 0.16. The data shows that disulfiram administration alters serotonin metabolism resulting in increased 5-HTOL which is known to increase alcohol consumption in rats. Since disulfiram is known to increase alcohol consumption in rats, an increase of 5-HTOL in humans may account for the lack of compliance in the use of disulfiram among alcoholics.

Department

Nutrition

School

Graduate School

First Advisor

Ulma D. Register

Second Advisor

Mickey N. Ask

Third Advisor

James W. Blankenship

Fourth Advisor

Gunter Reiss

Fifth Advisor

Albert Sanchez

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1987

Date (Title Page)

9-1987

Language

English

Library of Congress/MESH Subject Headings

Disulfiram -- adverse effects; Serotonin Antagonists; Alcoholism

Type

Dissertation

Page Count

iv; 12

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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