Abstract
The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where the selenite alone was non-toxic. Sodium selenite was found to enhance the fluorescence emission of Hpd and augment the Hpd-sensitized photooxidation of tryptophan. The data indicate that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.
LLU Discipline
Biology
Department
Biology
School
Graduate School
First Advisor
Benjamin H. S. Lau
Second Advisor
A. Graham Maxwell
Third Advisor
Elwood S. McCluskey
Fourth Advisor
Robert W. Teel
Degree Name
Master of Arts (MA)
Degree Level
M.A.
Year Degree Awarded
1986
Date (Title Page)
12-1986
Language
English
Library of Congress/MESH Subject Headings
Neoplasms -- therapy; Photochemotherapy; Cytotoxins; Selenium
Type
Thesis
Page Count
iii; 22
Digital Format
Digital Publisher
Loma Linda University Libraries
Copyright
Author
Usage Rights
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Recommended Citation
Tosk, Jeffrey M., "Selenium-induced Enhancement of Hematoporphyrin Derivative Phototoxicity in Murine Bladder Tumor Cells" (1986). Loma Linda University Electronic Theses, Dissertations & Projects. 744.
https://scholarsrepository.llu.edu/etd/744
Collection
Loma Linda University Electronic Theses and Dissertations
Collection Website
http://scholarsrepository.llu.edu/etd/
Repository
Loma Linda University. Del E. Webb Memorial Library. University Archives